Comparison:Article Title: Blood pressure targets in adults with hypertension
Article Snippet: Selective reporting (reporting bias) High risk Not all outcomes reported Other bias Low risk SMAC-AF 2017 Blood pressure targets in adults with hypertension (Review) Copyright © 2020 The Cochrane Collaboration.
Article Title: Blood pressure targets in adults with hypertension
Article Snippet: Comparison 1: Low vs Standard BP Target, Outcome 9: All other serious adverse events Study or Subgroup 1.9.1 Systolic target ACCORD 2010 Cardio-Sis 2008 PAST-BP 2016 SMAC-AF 2017 SPRINT 2015 SPS3 2013 Subtotal (95% CI) Total events: Heterogeneity: Chi2 = 11.64, df = 5 (P = 0.04); I2 = 57% Test for overall effect: Z = 7.68 (P < 0.00001) Total (95% CI) Total events: Heterogeneity: Chi2 = 11.64, df = 5 (P = 0.04); I2 = 57% Test for overall effect: Z = 7.68 (P < 0.00001) Test for subgroup differences: Not applicable Lower target Events 77 4 31 17 746 60 935 935 Total 2362 558 266 92 4678 1501 9457 9457 Standard target Events 30 2 16 14 553 33 648 648 Total 2371 553 263 92 4683 1519 9481 9481 Weight 4.6% 0.3% 2.5% 2.2% 85.4% 5.1% 100.0% 100.0% Risk Ratio M-H, Fixed, 95% CI 2.58 [1.70 , 3.91] 1.98 [0.36 , 10.78] 1.92 [1.07 , 3.42] 1.21 [0.64 , 2.32] 1.35 [1.22 , 1.50] 1.84 [1.21 , 2.80] 1.44 [1.32 , 1.59] 1.44 [1.32 , 1.59] Risk Ratio M-H, Fixed, 95% CI 0.02 0.1 1 10 50 Lower target Standard target Analysis 1.10.
Article Title: Atrial fibrillation: stroke prevention
Article Snippet: SMAC-AF 2017 , BP > 130/180 mmHg undergoing AF ablation , N = 184 , Intense blood pressure reduction , No difference in AF recurrence.
Article Title: Blood pressure targets in adults with hypertension
Article Snippet: Comparison 1: Low vs Standard BP Target, Outcome 7: Congestive heart failure Study or Subgroup 1.7.1 Systolic target ACCORD 2010 Cardio-Sis 2008 SMAC-AF 2017 SPRINT 2015 Subtotal (95% CI) Total events: Heterogeneity: Chi2 = 3.42, df = 2 (P = 0.18); I2 = 41% Test for overall effect: Z = 2.78 (P = 0.005) 1.7.2 Diastolic target ABCD (H) 2000 Subtotal (95% CI) Total events: Heterogeneity: Not applicable Test for overall effect: Z = 0.04 (P = 0.97) Total (95% CI) Total events: Heterogeneity: Chi2 = 3.78, df = 3 (P = 0.29); I2 = 21% Test for overall effect: Z = 2.72 (P = 0.007) Test for subgroup differences: Chi2 = 0.38, df = 1 (P = 0.54), I2 = 0% Lower target Events 72 3 0 62 137 9 9 146 Total 2362 558 92 4678 7690 237 237 7927 Standard target Events 80 7 0 100 187 9 9 196 Total 2371 553 92 4683 7699 233 233 7932 Weight 40.8% 3.6% 51.0% 95.4% 4.6% 4.6% 100.0% Risk Ratio M-H, Fixed, 95% CI 0.90 [0.66 , 1.24] 0.42 [0.11 , 1.63] Not estimable 0.62 [0.45 , 0.85] 0.73 [0.59 , 0.91] 0.98 [0.40 , 2.43] 0.98 [0.40 , 2.43] 0.75 [0.60 , 0.92] Risk Ratio M-H, Fixed, 95% CI 0.01 0.1 1 10 100 Lower target Standard target Analysis 1.8.
Article Title: Blood pressure targets in adults with hypertension
Article Snippet: The authors of SMAC-AF 2017 provided total serious adverse event information by email, in response to our request.
Article Title: Blood pressure targets in adults with hypertension
Article Snippet: Briefly, a specific SBP was required for inclusion in Schrier 2002 (> 140 mm Hg), Cardio-Sis 2008 (>150 mm Hg), SMAC-AF 2017 (>130 mm Hg), and SPRINT 2015 (between 130 mm Hg and 180 mm Hg).
Article Title: Blood pressure targets in adults with hypertension
Article Snippet: Comparison 1: Low vs Standard BP Target, Outcome 5: Myocardial infarction Study or Subgroup 1.5.1 Systolic target ACCORD 2010 Cardio-Sis 2008 PAST-BP 2016 SMAC-AF 2017 SPRINT 2015 SPS3 2013 Subtotal (95% CI) Total events: Heterogeneity: Chi2 = 0.28, df = 4 (P = 0.99); I2 = 0% Test for overall effect: Z = 1.87 (P = 0.06) 1.5.2 Diastolic target ABCD (H) 2000 HOT 1998 Subtotal (95% CI) Total events: Heterogeneity: Chi2 = 1.17, df = 1 (P = 0.28); I2 = 15% Test for overall effect: Z = 1.85 (P = 0.07) Total (95% CI) Total events: Heterogeneity: Chi2 = 1.77, df = 6 (P = 0.94); I2 = 0% Test for overall effect: Z = 2.56 (P = 0.01) Test for subgroup differences: Chi2 = 0.31, df = 1 (P = 0.58), I2 = 0% Lower target Events 126 4 1 0 97 36 264 16 125 141 405 Total 2362 558 266 92 4678 1501 9457 237 12526 12763 22220 Standard target Events 146 6 1 0 116 40 309 14 84 98 407 Total 2371 553 263 92 4683 1519 9481 233 6264 6497 15978 Weight 33.5% 1.4% 0.2% 26.7% 9.1% 71.0% 3.2% 25.8% 29.0% 100.0% Risk Ratio M-H, Fixed, 95% CI 0.87 [0.69 , 1.09] 0.66 [0.19 , 2.33] 0.99 [0.06 , 15.72] Not estimable 0.84 [0.64 , 1.09] 0.91 [0.58 , 1.42] 0.86 [0.73 , 1.01] 1.12 [0.56 , 2.25] 0.74 [0.57 , 0.98] 0.79 [0.61 , 1.02] 0.84 [0.73 , 0.96] Risk Ratio M-H, Fixed, 95% CI 0.01 0.1 1 10 100 Lower target Standard target Blood pressure targets in adults with hypertension (Review) Copyright © 2020 The Cochrane Collaboration.
Article Title: Blood pressure targets in adults with hypertension
Article Snippet: Comparison 1: Low vs Standard BP Target, Outcome 11: Diastolic blood pressure achieved Study or Subgroup 1.11.1 Systolic target ACCORD 2010 Cardio-Sis 2008 PAST-BP 2016 SMAC-AF 2017 SPRINT 2015 Schrier 2002 Subtotal (95% CI) Heterogeneity: Chi2 = 218.16, df = 5 (P < 0.00001); I2 = 98% Test for overall effect: Z = 58.97 (P < 0.00001) 1.11.2 Diastolic target ABCD (H) 2000 HOT 1998 REIN-2 2005 Toto 1995 Subtotal (95% CI) Heterogeneity: Chi2 = 107.75, df = 3 (P < 0.00001); I2 = 97% Test for overall effect: Z = 41.33 (P < 0.00001) Total (95% CI) Heterogeneity: Chi2 = 961.10, df = 9 (P < 0.00001); I2 = 99% Test for overall effect: Z = 67.46 (P < 0.00001) Test for subgroup differences: Chi2 = 635.19, df = 1 (P < 0.00001), I2 = 99.8% Lower target Mean 64.4 79.2 72 76.7 68.7 77 78 82.15 79.5 81 SD 7 7.5 9 11.4 7 7 5.17 5.05 5.3 6.48 Total 2362 558 266 92 4678 41 7997 237 12526 169 42 12974 20971 Standard target Mean 70.5 80.8 74.4 80.8 76.3 82.1 86 85.2 82.3 87 SD 7 7 8.9 10.2 7 7.4 5.24 5.1 7.1 5.92 Total 2371 553 263 92 4683 34 7996 233 6264 169 35 6701 14697 Weight 9.7% 2.1% 0.7% 0.2% 19.2% 0.1% 32.1% 1.7% 65.1% 0.9% 0.2% 67.9% 100.0% Mean Difference IV, Fixed, 95% CI -6.10 [-6.50 , -5.70] -1.60 [-2.45 , -0.75] -2.40 [-3.93 , -0.87] -4.10 [-7.23 , -0.97] -7.60 [-7.88 , -7.32] -5.10 [-8.38 , -1.82] -6.61 [-6.83 , -6.39] -8.00 [-8.94 , -7.06] -3.05 [-3.20 , -2.90] -2.80 [-4.14 , -1.46] -6.00 [-8.77 , -3.23] -3.18 [-3.33 , -3.03] -4.28 [-4.41 , -4.16] Mean Difference IV, Fixed, 95% CI -100 -50 0 50 100 Lower target Standard target Analysis 1.12.
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